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目的 探讨人工智能(artificial intelligence, AI)联合7项肿瘤相关自身抗体(CAGE、MAGE-A1、GBU4-5、GAGE7、SOX2、PGP9.5、P53,7-TAAbs)在Ⅰ期肺癌筛查中的价值。方法 纳入2023年7月～2024年12月我院70例低剂量CT检出的肺结节患者，经AI辅助诊断及病理分为肺癌组(40例)与良性结节组(30例),同时选取同期参加体检、LDCT未见明显异常且无恶性肿瘤及自身免疫性疾病病史的健康成人作为健康对照组，比较三组7-TAAbs的水平。结果 肺癌组6项抗体(除CAGE)浓度显著高于另两组(P<0.05);7-TAAbs单独检测阳性率45.0%,AI诊断AUC为0.688,7-TAAbs诊断AUC为0.692;二者联合AUC升至0.839,敏感度为75%,特异度为90%。结论 AI联合7-TAAbs检测可提高Ⅰ期肺癌检出率，对肺结节良恶性鉴别具有推广价值。
Abstract：Objective To investigate the value of artificial intelligence(AI) combined with 7 tumor-associated autoantibodies(CAGE,MAGE-A1,GBU4-5,GAGE7,SOX2,PGP9.5,P53,7-TAAbs) in stage I lung cancer screening.Methods A total of 70 patients with pulmonary nodules detected by low-dose CT at our hospital from July 2023 to December 2024 were enrolled.These patients were classified into a lung cancer group(40 cases) and a benign nodule group(30 cases) based on AI-assisted diagnosis and pathological examination.Concurrently, healthy adults who underwent physical examinations during the same period, showed no significant abnormalities on LDCT,and had no history of malignant tumors or autoimmune diseases were selected as the healthy control group.The levels of 7-TAAbs in the three groups were compared.Results The concentrations of 6 antibodies(except CAGE) in the lung cancer group were significantly higher than those in the other two groups(P<0.05).The positive rate of 7-TAAbs alone was 45.0%,the AUC of AI diagnosis was 0.688,and the AUC of 7-TAAbs diagnosis was 0.692.The combined AUC of the two was increased to 0.839,with a sensitivity of 75% and a specificity of 90%.Conclusion AI combined with 7-TAAbs detection can improve the detection rate of stage I lung cancer, which has generalizable value for the differentiation of benign and malignant lung nodules.
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基本信息:
DOI：10.16846/j.issn.1004-3101.2026.02.007
中图分类号:R734.2
引用信息:
[1]陶慧鑫,冯彦锟,王楚瑶,等.人工智能联合7项肿瘤相关自身抗体在Ⅰ期肺癌筛查中的临床意义[J].山东第二医科大学学报,2026,48(02):117-121.DOI:10.16846/j.issn.1004-3101.2026.02.007.
基金信息:
潍坊市卫生健康委员会科研项目(项目编号：WFWSJK-2023-320;WFWSJK-2023-242)
2026-04-14
2026-04-14